Who has a greater impact on the birth weight of the baby and the environment? Nature's new research gives the answer

September 30, 2016 Source: Bio Valley

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A recent large study conducted by multiple research institutes found that genetic differences can help explain why some babies have significant weight differences with other babies as soon as they are born. It also reveals how genetic differences can link a person's early life stages to the risk of type 2 diabetes and heart disease in later stages of life. The study, published in Nature, has found some new directions for the prevention and treatment of these diseases.

Researchers say at least one-sixth of the difference in birth weight is related to genetic differences between babies. This is seven to eight times the weight difference that can be explained by known environmental factors such as maternal smoking during pregnancy and pre-pregnancy BMI.

Scientists already know that if the baby's birth weight is significantly lower or higher than the average, it will greatly increase the risk of diabetes after several decades. Until now, many researchers still believe that this association reflects the long-term effects of the nutrient environment during fetal development: in other words, early life events can set a person's body, making them easier in later life. I am sick.

In the new study, the researchers found that genetic regions associated with differences in body weight and genetic regions associated with diabetes and heart disease risk overlap. In addition to the baby's own genes, the researchers also found that the mother's genes also affect the baby's weight, which may mainly play a role in changing the baby's environment during pregnancy.

The researchers analyzed genomic differences in nearly 154,000 people worldwide. By matching genetic information to birth weight information, the researchers found that 60 genomic regions significantly affected birth weight. They also analyzed previous research data on diabetes and heart disease and found that they contained many of the same genetic regions.

The researchers point out that these results suggest that genes play an important role in early growth and future disease risk, and they hope to have a deeper understanding of how mothers and babies' genes work together to affect your baby's weight and the risk of later life. .

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