PLoS Comput Biol: Heavy! New method to discover thousands of new cancer-related mutations

Release date: 2017-04-25

Scientists have identified thousands of previously overlooked genetic mutations. Although this mutation is rare, they may also contribute to cancer growth. These new findings paved the way for new treatments, and the results of the study were published in the journal PLOS Computational Biology.

When a gene mutation in a cell causes abnormal growth of the cell, cancer is produced. Some cancer drugs attack tumor cells by targeting mutant proteins encoded by mutant genes. However, only a few mutations that have made outstanding contributions to cancer have been identified.

Thomas Peterson of the University of Maryland and colleagues developed a new approach to data analysis. This method uses genetic data from cancer patients to identify mutations that cause cancer. Unlike previous concerns about individual gene mutations, the new approach focuses on similar mutations common to related protein families.

In particular, the new approach focuses on protein substructure mutations known as protein domains. Although these proteins are encoded by different genes, different proteins have a common protein domain. The new approach leverages existing knowledge and functions of protein domains to determine the location of protein domains that are more likely to be found in tumors.

Using this new approach, the researchers identified thousands of rare tumor mutations that occurred in the same location as other tumor protein mutations. This suggests that they may be related to cancer.

The study's senior author, Maricel Kann, said: "Perhaps only two patients have mutations in specific proteins. But when you find that it is in exactly the same position as other cancer patients' protein mutations, you will realize that these two studies The importance of a mutation."

Researchers have proposed "oncodomains" to refer to protein domains that are more likely to contain oncogenic mutations. Further research on tumor domains may contribute to drug development. "Because so many proteins have the same domain," Kann said. "So monotherapy may solve cancers caused by a large number of mutant proteins."

Source: Bio Valley (WeChat: BIOONNEWS)

Disposable Non Woven Shoe Covers

CE Certified Disposable Medical Shoe Covers:

Non woven shoe covers are made from higher GSM (40g) 100% non-woven material, waterproof, long lasting and comfortable to wear,which makes our shoe covers more resistant to tearing & rupturing. thicker and stronger compared to competitors (3g or less). The two ends of the cover shoes are heated sewing by ultrasonic, effectively prevent cracking and durable.
Normal size 40X17cm. The high-quality elastic rubber strap fits most shoes and is easy to put on and take off.
The surface has a concave-convex texture design, effective anti-slip,ensure your safety in various situations. With soft material, breathable and lightweight, prevent dust from your shoe covers, no more stuffy or smelly, has a better permeability than ordinary plastic shoes covers.
Easy and effective to keep your shoes,carpets,hardwood and home floors clean, protect them against dirt, grime, and certain dry particulates that upset you.Great suit for indoor carpet floor, workplace, cars,garden,medical,construction, open house showing, homes, restaurant, auto cleanroom, rain weather, gardening, parties, museum, and sports.Perfect for painters, realtors ,real-estate agent, home service workers & inspector, movers, contractors, workmen, plumbers, guards.

Shoe Covers Disposable Non Slip,Disposable Shoe Covers For Indoors,Non Slip Shoe Covers Disposable,Shoe Covers For Indoors Disposable

Suzhou JaneE Medical Technology Co., Ltd. , https://www.janeemedical.com