"Nature": Han Chunyu has found that others can not repeat the experimental reasons
Release date: 2016-11-25
The paper on the new gene editing technology published by Han Chunyu of the Hebei University of Science and Technology in China has caused great controversy at home and abroad for several months. A news report published on the 23rd of the British Nature magazine quoted Han Chunyu as saying that he had discovered a problem that was not easy to attract attention. This may explain why it is difficult for others to repeat the experiments he described in the paper.
In May of this year, Han Chunyu team reported in the world's famous academic journal Nature, "Bio-Biotechnology" that they invented a new gene editing technology NgAgo-gDNA. According to the paper, NgAgo-gDNA technology has advantages in some aspects compared with the mainstream technology CRISPR-Cas9 in the field of genetic editing. But then scholars in China and abroad have publicly stated that the experiments described in the paper cannot be repeated. The results of this research have been questioned by many parties.
The news report of Nature quoted Han Chunyu as saying that he has now discovered a problem that is not easy to attract attention. It may explain why it is difficult for others to repeat the experiment he described in the paper. He is currently conducting experiments to further confirm After the results, he will publish the data and related information. He told Nature that he still needs a little time.
The report also mentioned that some scientists have said in an interview with the magazine that they can use the experimental methods described by the Han Chunyu team in the paper to obtain preliminary results, but one of the scientists' latest sayings is that the relevant data is confusing. It is impossible to draw a conclusion now. Nature says that these scientists are reluctant to reveal their identity in order to avoid being involved in the dispute.
Han Chunyu said in an interview with the media that his paper is true. He has repeated experiments many times, but the voice of doubt still appears. However, relevant discussions have recently entered the formal academic track from public opinion concerns.
On November 11th, researchers from institutions such as Nantong University in China published a paper in the journal Nature Research, which reported that NgAgo technology can be used to “knock down†genes in zebrafish models, but this was not found. The technology has the function of "editing" genes. The researchers said that because of the different research subjects, the study "cannot support or refute the experimental results of previous Han Chunyu."
On November 15th, the international academic journal "Protein and Cell" published an article entitled "Questions about NgAgo", which was jointly signed by scientists from many laboratories at home and abroad. The article was described in the paper by Han Chunyu team. The results of the experiment were questioned, indicating that the experiment could not be repeated. At the same time, the authors also called on Han Chunyu team to clarify the doubts as soon as possible and provide more detailed experimental data.
According to a report on the Nature magazine website, the editorial board of Nature·Biotechnology is still investigating the incident. The editorial department of Nature·Biotechnology issued a statement in early August saying that in view of the huge controversy caused by Han Chunyu's paper, the matter will be investigated according to the established process. The news report also said that the journalism team of Nature and the editorial department of Nature Biotechnology are two teams that operate independently of each other.
Source: Xinhua News Agency
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