Live cytotoxin nano detectors come out

Release date: 2008-12-22

American scientists have recently developed a miniature nano-detector that can detect carcinogenic toxins in living cells or track the effectiveness of cancer drugs. This is a new tool for tracking specific chemicals in your body. The research results were published in the 14th issue of Nature? Nanotechnology.
The researchers implanted carbon nanotubes into DNA molecules to make sensors for insertion into living cells. This carbon nanotube sensor can detect a variety of specific DNA-damaging substances, such as certain toxin molecules, free radicals, and some cancer chemotherapy drugs. It locates the exact location of these molecules within the cell, especially for hydrogen peroxide, an oxidant that can be probed to a single molecule.
Sensors developed by the Massachusetts Institute of Technology research team encapsulated carbon nanotubes with DNA to allow them to bind to the "agent" of DNA damage within the cell. The sensor emits fluorescence that can be detected near the near-infrared spectrum, because human tissue does not illuminate in this spectrum, and the nanotubes are therefore prominent.
When the sensor interacts with the DNA inside the cell, the light signal changes, and these changes can help the researcher identify a particular molecule. Because the sensors are coated in DNA, they can be safely injected into living cells. Eventually, the detector will "stand out" by phagocytizing the protein on the surface of the coating.
This cell "detector" can be used for chemotherapy monitoring in cancer patients to ensure that chemotherapy drugs work effectively. The researchers explained that many chemotherapeutic drugs are extremely destructive to the DNA inside the cell, causing serious side effects, so using this "detector" can help doctors monitor whether the drug has the right target - cancer cells. In addition, it can also detect oxidants such as hydrogen peroxide.
——Shanghai Medical Device Industry Association

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