Subversion of textbooks, adult cardiomyocytes can be "regenerated"
Subversion of textbooks, adult cardiomyocytes can be "regenerated"
June 28, 2017 Source: Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Adult cardiomyocytes are cells that cannot be regenerated, and this cognition written into medical textbooks is expected to be completely subverted. Zeng Chunyu, director of the Department of Cardiology, Daping Hospital, Third Military Medical University, used the latest experimental results to visually show that adult cardiomyocytes not only have the ability to regenerate, but also have their contractile function after regulation. The team's myocardial regeneration research group, Associate Professor Wang Wei and others, spent six years researching and published this achievement online on June 23 in the international cardiovascular journal "Circulation".
Loss of cardiomyocytes is the main pathological process during the development of myocardial infarction and heart failure. Current clinical treatments such as drugs, interventional stents, and coronary artery bypass surgery have delayed the disease to a certain extent, but they cannot reverse the development of the disease. However, cardiomyocytes and nerve cells and skeletal muscle cells are regarded as cells that have no regenerative ability or weak regeneration ability, and are defined as permanent cells by medical textbooks. Once damaged, they are permanently lost. "Myocardial regeneration" is considered to be impossible. Realizing the dream.
After solving the key techniques of in vitro adult cardiomyocyte culture, the research team used the living cell workstation to visually display the whole process of myocardial cell division and to study the mechanism of its proliferation and division. Induction by appropriate conditions allows cardiomyocytes to have a strong proliferative capacity, with a proliferation rate of 7.0%, which is 14 times higher than 0.5% of foreign studies. The experiment also found that the terminally differentiated double/multicore muscle cells and the single-core muscle cells have similar proliferative abilities, rewriting the view that in the past academic circles, "only a small number of naive single-core muscle cells have the potential to proliferate." The research team further found in cell experiments and animal experiments that these terminally differentiated cardiomyocytes regenerate new cardiomyocytes in a process of "de-differentiation-proliferation-redifferentiation".
According to Zeng Chunyu, the study reveals the biological characteristics of adult myocardial proliferation and the important pathways of endogenous regeneration of the myocardium, and identifies the specific molecular mechanism of myocardial re-differentiation, which brings dawn to clinical treatment of myocardial infarction and heart failure. (Zhu Guangping, Zou Zhengchun, reporter Chen Lei)
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