Is it future to personalize 3D printed drugs for treatment?
[ China Pharmaceutical Network Technology News ] Will 3D printing drugs be the future? FabRx is a company seeking commercial 3D printing of drugs and equipment, founded in 2014 by scholars at University College London (UCL). Dr. Alvaro Goyanes is one of the four founding partners and development director of FabRx. He invited the 3D printing industry to enter the lab of the UCL Pharmaceutical Institute to learn more about the ongoing research at FabRx.
Placebo and paracetamol
In the lab, Dr. Goyanes showed me a series of drugs developed by the company using its trademark Printlets technology. All of these drugs use the FFF 3D printing process, and the printed materials are the company's own wire.
The lab is equipped with a four-nozzle MakerBot 3D printer that prints a variety of materials. Dr. Goyanes explained that in a 3D printed tablet, "different layers may contain different drugs, or the same drug, but the release rate in the stomach is different, so we can control the dissolution of the drug."
At this stage, FabRx's 3D printed tablets are either placebo or contain different concentrations of paracetamol (a commonly used antipyretic analgesic).
Various shapes and sizes of medicines
Placebo Printlets are made from proven, biocompatible excipients that are soluble in the human body, some of which are stained with food dyes purchased from supermarkets. In contrast, 3D printed paracetamol tablets are currently only used in preclinical trials. The lab is also experimenting with various different types of placebo tablets to understand how people respond to them.
Dr. Goyanes explained the idea behind various shapes. “With regard to personalized medicine, we always talk about how to change the size of the drug so that the dosage of the formula can be adjusted according to the specific needs of each person. Since the size is changed, the shape can also be changed. In one study, we are trying all these crazy shapes."
The lab has tested these unique 3D printed Printlets on people and responded well. The 30 people involved in the experiment were positive about the structure and technical attitude of the tablets and showed a preference for a particular color or shape. The full results of this study will be announced later this year.
Personalize treatment
Regarding the transformation of traditional large-scale drug production methods, Dr. Goyanes explained: “Our idea is to introduce these printers into hospitals or pharmacies. We will provide wire or raw materials, and then doctors or pharmacists will choose the right dose for the patient, possibly combining Different drugs, then just click the button, print, and finally 3D print the drug to the patient."
However, he added that there is still some way to go. When asked about the main obstacles to 3D printing drugs, Dr. Goyanes said: "Technology is already there, but we must develop and follow the rules."
(Let the treatment of personalized 3D printed drugs a future?)
Placebo and paracetamol
In the lab, Dr. Goyanes showed me a series of drugs developed by the company using its trademark Printlets technology. All of these drugs use the FFF 3D printing process, and the printed materials are the company's own wire.
The lab is equipped with a four-nozzle MakerBot 3D printer that prints a variety of materials. Dr. Goyanes explained that in a 3D printed tablet, "different layers may contain different drugs, or the same drug, but the release rate in the stomach is different, so we can control the dissolution of the drug."
At this stage, FabRx's 3D printed tablets are either placebo or contain different concentrations of paracetamol (a commonly used antipyretic analgesic).
Various shapes and sizes of medicines
Placebo Printlets are made from proven, biocompatible excipients that are soluble in the human body, some of which are stained with food dyes purchased from supermarkets. In contrast, 3D printed paracetamol tablets are currently only used in preclinical trials. The lab is also experimenting with various different types of placebo tablets to understand how people respond to them.
Dr. Goyanes explained the idea behind various shapes. “With regard to personalized medicine, we always talk about how to change the size of the drug so that the dosage of the formula can be adjusted according to the specific needs of each person. Since the size is changed, the shape can also be changed. In one study, we are trying all these crazy shapes."
The lab has tested these unique 3D printed Printlets on people and responded well. The 30 people involved in the experiment were positive about the structure and technical attitude of the tablets and showed a preference for a particular color or shape. The full results of this study will be announced later this year.
Personalize treatment
Regarding the transformation of traditional large-scale drug production methods, Dr. Goyanes explained: “Our idea is to introduce these printers into hospitals or pharmacies. We will provide wire or raw materials, and then doctors or pharmacists will choose the right dose for the patient, possibly combining Different drugs, then just click the button, print, and finally 3D print the drug to the patient."
However, he added that there is still some way to go. When asked about the main obstacles to 3D printing drugs, Dr. Goyanes said: "Technology is already there, but we must develop and follow the rules."
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