Injectable self-assembled nano gold particles-collagen composite hydrogel for anti-tumor photodynamic/photothermal therapy
Release date: 2016-06-16
In recent years, injectable, self-healing hydrogels based on self-assembly of proteins and peptides are particularly in the biological field due to their inherent biocompatibility, biodegradability, adjustable mechanical properties and environmental responsiveness. It is a growing concern in the biomedical field. Some natural proteins such as elastin, collagen, gelatin, and silk fibroin are widely used in the self-assembly synthesis of hydrogels because of their abundant resources. However, self-assembly of collagen hydrogels has poor mechanical properties, which limits its use as an injectable material in drug delivery and tissue engineering.
Recently, Professor Jiao Tifeng from the School of Environmental and Chemical Engineering of Yanshan University and the research team of Yan Xuehai from the Institute of Process Engineering of the Chinese Academy of Sciences have successfully prepared nano-gold particle-collagen composite hydrogels by supramolecular self-assembly. Their paper was published in Advanced Materials. Ruirui Xing, a Ph.D. student of Professor Jiao Tifeng's research group, was the first author of the paper. Kai Liu, a Ph.D. student of Yan Xuehai's research group, was the co-first author of the paper. Jiao Tifeng Professor, Yan Xuehai, and Zou Qianli, associate researcher, are co-authors. (An Injectable Self-Assembling Collagen–Gold Hybrid Hydrogel for Combinatorial Antitumor Photothermal/Photodynamic Therapy. Advanced Materials, DOI: 10.1002/adma.201600284)
The gold nanoparticles formed by in-situ mineralization have been confirmed to have the function of regulating the mechanical properties of collagen hydrogel. The weak force between the nano gold particles and the collagen gel system gives the hydrogel shear thinning and self-healing properties. . This collagen-based hydrogel-based strategy can be applied to the construction of various functional hydrogels. Biopolymers such as chitosan, silk fibroin, elastin and gelatin can interact electrostatically with ionic clusters. Self-assembly forms a hydrogel. In addition, this biocompatible collagen hydrogel can be used as a novel tool for drug retention and sustained drug release. It has many advantages, such as reducing drug use, reducing drug toxicity, and improving bioavailability. This hydrogel material has also been shown to be combined with photodynamic/photothermal, which significantly enhances the anti-tumor effect. The treatment uses an intratumoral hydrogel injection and multiple local light treatments. No pathological damage of the main organs was found.
In summary, they developed injectable, self-healing collagen composite hydrogels, providing new alternative vehicles for biomedical applications such as drug delivery and tissue engineering, with broad application prospects.
The research work was supported by the China Youth Organization Thousand Talents Program, the Chinese Academy of Sciences International Talent Exchange Program, the National Natural Science Foundation, the Natural Science Foundation of Hebei Province, the first batch of youth talent support programs in Hebei Province, and the China Postdoctoral Science Foundation. .
Http://onlinelibrary.wiley.com/doi/10.1002/adma.201600284/full
Source: X-MOL
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