Mao Dongqing's pharmacological effects
Pharmacological effects
Cardiovascular effects:
Hairy flavonoids in the isolated rabbit heart, escort dog heart, dog cardiopulmonary device experiments, increase coronary flow and strong, but long, but began to slow, in place dogs 30 to 40 minutes after intravenous injection of significant effect, One dose can be maintained for 2 to 3 hours, while nitroglycerin is only 6 to 8 minutes and sodium nitrite is 14 to 15 minutes. At the same time as expanding coronary artery increases flow, most dogs have only slightly increased myocardial oxygen consumption or Even reduction, no effect on cardiac activity, most animal heart rate slows down, which is beneficial to patients with myocardial hypoxia caused by coronary spasm or myocardial infarction. Maodongqing flavonoids are repeatedly applied in a short period of time and are rapidly tolerated, and clinical efficacy of continuous application is reduced. Maodong Dong crude product (ethanol extract solution of decoction) can attenuate coronary blood flow in normal rabbits and left rabbit coronary arteries after ligation for 3 months before left coronary artery ligation. Most experiments show that There was no significant effect on heart rate and heart rate. In isolated guinea pig hearts, the coronary flow was increased while the cardiac contractility was increased, but the heart rate was not affected. The Shushuning injection (10mg/mL flavonoids), prepared by bald Holly llexpubescensHook.EtArn.Var.GlabraChang, also increased the coronary artery flow in isolated rabbit hearts and in situ dogs. Maodongqing crude product has a protective effect on T wave changes of myocardial ischemia in rabbits induced by pituitrin, but it has also been reported that Maodongqing injection (flavonoids content 40mg/2mL) is intraperitoneally injected into rat at 1mL/kg. , For 5 consecutive days, there was no protective effect on the myocardial ischemia induced by pituitrin. The antihypertensive effect of flavonoids of Maodongqing is slow and long-lasting. Even after intravenous injection, most people can see the obvious antihypertensive effect after 20 to 30 minutes, and the antihypertensive effect is reduced in 1 to 3 hours, while the antihypertensive effect of nitrites is reduced. The occurrence of rapid and severe, 3 hypertensive dogs daily oral Mao Dongqing decoction 4g (crude drug) / kg, a total of 6 days, no significant changes in blood pressure and pulse. There are inconsistent reports on the effects of blood pressure on people. The role of flavonoids in Mao Dongqi flavonoids in dilating blood vessels may be in the periphery, and atropine can block its antihypertensive effect, and thus is related to receptors of parasympathetic nerve endings.
Effects on Lipid Metabolism: Intramuscular injection of Maodongqing in rabbits with experimental atherosclerosis without
A clear hypocholesterolemic effect, preventive treatment and advanced treatment had no effect on the formation of atherosclerotic plaque in the aorta, but the early repeat treatment seemed to slightly reduce the trend.
Antimicrobial effects: Preliminary antibacterial tests showed that Staphylococcus aureus is extremely sensitive to hairy holly; deformation, dysentery (Fauer) and Pseudomonas aeruginosa are also sensitive.
Antitussive and expectorant effects: The decoction of root of holly root has antitussive effect on the cough caused by sulfur dioxide in mice.
Swabs are ideal for collecting large numbers of samples and quickly eluting samples. It immediately releases specimens into transport media and is widely used in molecular genetics, forensic science, clinical laboratories, and more.
Sponge Swab,Medical disposable sample collection sample flocking swab,A tube flocking swab for the collection of nasal cell samples,Single use
Jiangsu iiLO Biotechnology Co., Ltd. , https://www.sjiilobiotech.com