Raw 98% Purity Quinine Powder Effect on Antimalarial 130-95-0

Product Description

Raw 98% purity Quinine powder effect on Antimalarial


Product name: Quinine
Alias: Chinin; Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-; Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-; Kinin; Quinina;
CAS Number: 130-95-0
EINECS number: 205-003-2
Molecular Formula: C20H24N2O2
Molecular weight: 322.41700
Appearance and properties: Orthorhombic needles, odorless
Density: 1.21g/cm3
Melting point: 176-177oC
Boiling point: 495.9oC at 760mmHg
Flash point: 253.7oC
Refractive index: 1.625 (15oC)
Stability: Stable under normal temperatures and pressures. May discolor on exposure to light.
Storage conditions: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40oC.
Steam pressure: 0mmHg at 25°C
Packing level: III
Hazard Category: 6.1(b)
Customs Code: 29392110
Dangerous goods transport code: UN 1544
WGK Germany: 3
Hazard category code: R22; R36/37/38
Safety instructions: S26-S37/39
Dangerous goods mark: Xn


Quinine is a quinoline derivative and has a strong killing effect on various erythrocytic schizonts of Plasmodium. It can combine with Plasmodium DNA to form complexes, inhibit DNA replication and RNA transcription, thereby inhibiting the protein synthesis of protozoa, but the effect is weaker than chloroquine. It can also reduce the oxygen consumption of Plasmodium, inhibit the phosphorylase in Plasmodium and interfere with its sugar metabolism. It also causes agglutination of malarial pigments, but it develops slowly and rarely forms large clumps. In the blood, a certain concentration of Quinine can lead to premature rupture of the parasitized red blood cells, thus preventing the schizont from maturing. Quinine has no effect on the infrared phase and does not cure benign malaria. A long course of treatment can cure P. falciparum, but it has no direct effect on the gametophyte of P. falciparum, so it cannot interrupt transmission. In addition, Quinine has an inhibitory effect on the myocardium, prolongs the refractory period, slows conduction, and weakens its contractility. There is a weak excitatory effect on the uterus during pregnancy.

Quinine COA: 
 

Effect

Quinine is an important antimalarial drug for the erythrocytic protozoa of P. falciparum that inhibits its reproduction or kills it. Quinine also inhibits myocardial contractility and increases uterine rhythmic contraction.

Taboo
Pregnant women are disabled, quinine has oxytocin, can pass the placenta, causing fetal hearing damage and congenital defects of the central nervous system, limbs. Nursing women with caution.
For patients with asthma, atrial fibrillation and other severe heart diseases, glucose-6-phosphate dehydrogenase deficiency, myasthenia gravis, and optic neuritis should be used with caution.
Cardiomyopathy and pregnant women are disabled. Treatment of cerebral malaria with quinine is dangerous, and it is dangerous for people who are allergic to quinine.

Steroids Injection  List

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How to order quickly and safely? 

 

 
Packaging





















Shipping Method






















 
Company Information
Hubei Shinrezing Pharmaceutical Technology Co.,Ltd.(hereafter shorted as Shinrezing) is located in Wuhan Donghu High-Tech Economic Development Zone and established in 2008 with registered capital is RMB 10 million yuan (about USD 1.5 million ). Its manufacturing base is located in Dawu Industrial Park in Dawu County, Xiaogan City, Hubei Province which is built in 2010 with 25,000 square meters covered area.
 
Shinrezing is a rapid growing enterprise, which integrates the production, R&D, sales and trading of APIs, steroid raw materials, pharmaceutical intermediates, plant extracts, other kinds of organic intermediates etc. Shinrezing is not only a manufacturing company but also a trade company, it also has very good cooperation relationships with some manufacturers qualified with GMP, DMF to meet the different customers' needs from grams to tonnage quantity, which makes Shinrezing to be more flexible and easily to supply highly cost-effective products with high quality and better service to customers.
Shinrezing always stands in high starting, high stand and high quality, and masters strict management for production procedure and quality control. All the products must pass our quality test before being sending to customers. Shinrezing's products have been exported to more than 50 countries and regions all over the world, including United States, Europe, Japan, Korea, Russia, Hong kong, Taiwan and so on, and enjoy a good reputation from domestic and oversea customers
 
Shinrezing's mission is: "Innovative and Pragmatic, Mutual Benefits, Serve the World". Every staff member will keep this in mind all the time, and enforce it at every detail of operation and management of the company. We are always trying our best to offer the best services and the most competitive prices with high quality goods for our customers. All honors belong to the past, Shinrezing people will do their best to develop and produce more perfect product and contribute to the chemical pharmaceutical industries worldwide.

We are confident that Shinrezing will be your best solution.





 
FAQ
Order Guide
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept bank transfer, Western Union or Paypal or  Moneygram

Q6:How long does it take to the goods arrived ?
It is Depending on your location,
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost shouldundertake by your side.
 
We have formed a technology and management team that cooperate closely with some  overseas Labs  all speak highly of our safe shipping and goods .
please donot hesitate to contact us.
 

Product Description

Raw 98% purity Quinine powder effect on Antimalarial


Product name: Quinine
Alias: Chinin; Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-; Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-; Kinin; Quinina;
CAS Number: 130-95-0
EINECS number: 205-003-2
Molecular Formula: C20H24N2O2
Molecular weight: 322.41700
Appearance and properties: Orthorhombic needles, odorless
Density: 1.21g/cm3
Melting point: 176-177oC
Boiling point: 495.9oC at 760mmHg
Flash point: 253.7oC
Refractive index: 1.625 (15oC)
Stability: Stable under normal temperatures and pressures. May discolor on exposure to light.
Storage conditions: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40oC.
Steam pressure: 0mmHg at 25°C
Packing level: III
Hazard Category: 6.1(b)
Customs Code: 29392110
Dangerous goods transport code: UN 1544
WGK Germany: 3
Hazard category code: R22; R36/37/38
Safety instructions: S26-S37/39
Dangerous goods mark: Xn


Quinine is a quinoline derivative and has a strong killing effect on various erythrocytic schizonts of Plasmodium. It can combine with Plasmodium DNA to form complexes, inhibit DNA replication and RNA transcription, thereby inhibiting the protein synthesis of protozoa, but the effect is weaker than chloroquine. It can also reduce the oxygen consumption of Plasmodium, inhibit the phosphorylase in Plasmodium and interfere with its sugar metabolism. It also causes agglutination of malarial pigments, but it develops slowly and rarely forms large clumps. In the blood, a certain concentration of Quinine can lead to premature rupture of the parasitized red blood cells, thus preventing the schizont from maturing. Quinine has no effect on the infrared phase and does not cure benign malaria. A long course of treatment can cure P. falciparum, but it has no direct effect on the gametophyte of P. falciparum, so it cannot interrupt transmission. In addition, Quinine has an inhibitory effect on the myocardium, prolongs the refractory period, slows conduction, and weakens its contractility. There is a weak excitatory effect on the uterus during pregnancy.

Quinine COA: 
 

Effect

Quinine is an important antimalarial drug for the erythrocytic protozoa of P. falciparum that inhibits its reproduction or kills it. Quinine also inhibits myocardial contractility and increases uterine rhythmic contraction.

Taboo
Pregnant women are disabled, quinine has oxytocin, can pass the placenta, causing fetal hearing damage and congenital defects of the central nervous system, limbs. Nursing women with caution.
For patients with asthma, atrial fibrillation and other severe heart diseases, glucose-6-phosphate dehydrogenase deficiency, myasthenia gravis, and optic neuritis should be used with caution.
Cardiomyopathy and pregnant women are disabled. Treatment of cerebral malaria with quinine is dangerous, and it is dangerous for people who are allergic to quinine.

Steroids Injection  List

Other products:

 

How to order quickly and safely? 

 

 
Packaging





















Shipping Method






















 
Company Information
Hubei Shinrezing Pharmaceutical Technology Co.,Ltd.(hereafter shorted as Shinrezing) is located in Wuhan Donghu High-Tech Economic Development Zone and established in 2008 with registered capital is RMB 10 million yuan (about USD 1.5 million ). Its manufacturing base is located in Dawu Industrial Park in Dawu County, Xiaogan City, Hubei Province which is built in 2010 with 25,000 square meters covered area.
 
Shinrezing is a rapid growing enterprise, which integrates the production, R&D, sales and trading of APIs, steroid raw materials, pharmaceutical intermediates, plant extracts, other kinds of organic intermediates etc. Shinrezing is not only a manufacturing company but also a trade company, it also has very good cooperation relationships with some manufacturers qualified with GMP, DMF to meet the different customers' needs from grams to tonnage quantity, which makes Shinrezing to be more flexible and easily to supply highly cost-effective products with high quality and better service to customers.
Shinrezing always stands in high starting, high stand and high quality, and masters strict management for production procedure and quality control. All the products must pass our quality test before being sending to customers. Shinrezing's products have been exported to more than 50 countries and regions all over the world, including United States, Europe, Japan, Korea, Russia, Hong kong, Taiwan and so on, and enjoy a good reputation from domestic and oversea customers
 
Shinrezing's mission is: "Innovative and Pragmatic, Mutual Benefits, Serve the World". Every staff member will keep this in mind all the time, and enforce it at every detail of operation and management of the company. We are always trying our best to offer the best services and the most competitive prices with high quality goods for our customers. All honors belong to the past, Shinrezing people will do their best to develop and produce more perfect product and contribute to the chemical pharmaceutical industries worldwide.

We are confident that Shinrezing will be your best solution.





 
FAQ
Order Guide
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept bank transfer, Western Union or Paypal or  Moneygram

Q6:How long does it take to the goods arrived ?
It is Depending on your location,
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost shouldundertake by your side.
 
We have formed a technology and management team that cooperate closely with some  overseas Labs  all speak highly of our safe shipping and goods .
please donot hesitate to contact us.