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Metabolic molecules associated with aging in the blood

A group of scientists in the UK have discovered a revolutionary result: through blood tests, you can determine how long a person can live and how fast aging is. The research team discovered a chemical "fingerprint" in human blood that can be used to determine a person's health and aging rate.
The relevant research report was published in the International Journal of Epidemiology on the 9th. According to reports, the researchers identified 22 metabolic molecules in the blood that are associated with the rate of aging in the human body and the diseases that may occur in old age. Among the 22 metabolic molecules, one is named C-glyTrp, which is closely related to a person's lung function, bone density, blood pressure and cholesterol levels. They believe that the level of C-glyTrp metabolic molecules will determine the rate of aging after a person grows up.
In addition, the metabolic molecule is also thought to be related to the body weight at birth. The weight of a baby at birth was previously considered to be an important factor in a person's health and aging. The results of this research may allow doctors to take appropriate measures for newborns to avoid the corresponding symptoms in their old age. In addition, based on this finding, new treatment drugs or means may be developed for diseases related to aging such as bone problems and heart diseases.
Tim Spekert, a research team leader and professor at King's College London, said: "Scientists have long discovered that the weight of a person at birth is an important reference for the health of middle-aged and old-aged people. Generally speaking, People who are born at a lower weight are more likely to develop aging-related diseases in old age."
“Previously, the relationship between birth weight and aging health status has not been explained by a clear molecular mechanism, but our latest findings indicate that at least one metabolic molecule can confirm the relationship between the two.”
According to reports, Spector's research team conducted a laboratory analysis of blood samples from more than 6,000 twins, and found 22 metabolic molecules directly related to aging. Identical twins share the same genes, but the birth weights between the twins tend to be different. Researchers believe that this indicates that the level of C-glyTrp metabolic molecules changes due to differences in the nutrients absorbed by the fetus in the uterus.
Research team member Anna Valdes said: "The process of human aging is controlled by factors such as genes, living habits, and environment. Our research has for the first time found that by testing blood, we can identify metabolic molecules related to the rate of aging. Knowing these metabolic molecules, we can develop anti-aging drugs and therapies. The significance of this discovery is that these metabolic molecules are detectable in the blood, so we can understand ourselves through a simple blood test. How long can I live?"
Metabolomic markers reveal novel pathways of ageing and early development in human populations
Abstract

Background Human ageing is a complex, multifactorial process and early developmental factors affect health outcomes in old age.

Methods Metabolomic profiling on fasting blood was carried out in 6055 individuals from the UK. Stepwise regression was performed to identify a panel of independent metabolites which could be used as a surrogate for age. We also investigated the association with birthweight overall and within identical discordant twins And with genome-wide methylation levels.

Results We identified a panel of 22 metabolites which combined are strongly correlated with age (R 2 = 59%) and with age-related clinical traits independently of age. One particular metabolite, C-glycosyl tryptophan (C-glyTrp), Age (beta = 0.03, SE = 0.001, P = 7.0 × 10 −157 ) and lung function (FEV 1 beta = −0.04, SE = 0.008, P = 1.8 × 10 −8 adjusted for age and confounders) and was replicated in An independent population ( n = 887). C-glyTrp was also associated with bone mineral density (beta = −0.01, SE = 0.002, P = 1.9 × 10 −6 ) and birthweight (beta = −0.06, SE = 0.01, P = 2.5 × 10 −9 ). The difference in C-glyTrp levels explained 9.4% of the variance in the difference in birthweight between monozygotic twins. An epigenome-wide association study in 172 people identified three CpG-sites, associated with levels of C -glyTrp ( P < 2 × 10 −6 ). We replicated one CpG site in the promoter of the WDR85 gene in an independent sample of 350 Individuals (beta = −0.20, SE = 0.04, P = 2.9 × 10 −8 ). WDR85 is a regulator of translation elongation factor 2, essential for protein synthesis in eukaryotes.

Conclusions Our data illustrates how metabolomic profiling linked with epigenetic studies can identify some key molecular mechanisms potentially determined in early development that produce long-term physiological changes influencing human health and ageing.

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