Egfr Gefitinib White Raw Powder CAS: 184475-35-2 with Top Quality

Model NO.: 184475-35-2
Name: Gefitinib
CAS: 184475-35-2
Property: White Powder
Package: 1kg/Carton Drum
Delivery: Within 24 Hours After Payment Confirmed
Shipment: EMS, FedEx, TNT, DHL, UPS
Shiping Port: Shanghai, Shenzhen, Canton, Guangzhou.Hongkong
Supply Ability: Bulk
Shipping: Discreet
Trademark: JCJCHEM
Transport Package: 25kg/Carton Drum
Specification: COA
Origin: China
HS Code: 122
Model NO.: 184475-35-2
Name: Gefitinib
CAS: 184475-35-2
Property: White Powder
Package: 1kg/Carton Drum
Delivery: Within 24 Hours After Payment Confirmed
Shipment: EMS, FedEx, TNT, DHL, UPS
Shiping Port: Shanghai, Shenzhen, Canton, Guangzhou.Hongkong
Supply Ability: Bulk
Shipping: Discreet
Trademark: JCJCHEM
Transport Package: 25kg/Carton Drum
Specification: COA
Origin: China
HS Code: 122
EGFR Gefitinib White Raw Powder CAS: 184475-35-2 with Top Quality

Technical Data:

M. Wt: 446.9
Formula: C22H24ClFN4O3
Storage: Store at RT
Purity: ≥98% (HPLC)
CAS Number: 184475-35-2
PubChem ID: 123631
InChI Key: XGALLCVXEZPNRQ-UHFFFAOYSA-N
Solubility: DMSO (44.69), ethanol (4.47)

COA:

 
Product name  
Gefitinib
 
CAS No.  
184475-35-2
Outer Packing  
1KG
 
Production date  
May,05,2016
Shelf life  
May.04,2019
Standard adopted  
 
house standard
Items of analysis Specification Results
 
 
Appearance
 
 
White to off-white powder
 
 
off-White powder
 
 
Identifcation
 
 
HPLC(RT)
 
 
Complies
 
 
Loss on drying
 
 
≤ 0.5%
 
 
0.13%
 
 
Residue on ignition
 
 
≤0.,1%
 
 
0.1%
 
 
Max Single Impurity
 
 
≤ 0.10 %
 
 
0.09%
 
 
Total Impurity
 
 
≤.1.0%
 
 
0.24%
 
 
Purity(HPLC)
 
 
≥99%
 
 
99.76%
Conclusion Qualified

Mechanism of action:

Gefitinib is the first selective inhibitor of epidermal growth factor receptor's (EGFR) tyrosine kinase domain. Thus gefitinib is an EGFR inhibitor. The target protein (EGFR) is a member of a family of receptors (ErbB) which includes Her1(EGFR), Her2(erb-B2), Her3(erb-B3) and Her4 (Erb-B4). EGFR is overexpressed in the cells of certain types of human carcinomas - for example in lung and breast cancers. This leads to inappropriate activation of the anti-apoptotic Ras signalling cascade, eventually leading to uncontrolled cell proliferation. Research on gefitinib-sensitive non-small cell lung cancers has shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways.These mutations tend to confer increased sensitivity to tyrosine kinase inhibitors such as gefitinib and erlotinib. Of the types of non-small cell lung cancer histologies, adenocarcinoma is the type that most often harbors these mutations. These mutations are more commonly seen in Asians, women, and non-smokers (who also tend to more often have adenocarcinoma).

Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme.Thus the function of the EGFR tyrosine kinase in activating the anti-apoptotic Ras signal transduction cascade is inhibited, and malignant cells are inhibited.

How to use Gefitinib Tablet:

Take gefitinib by mouth once daily, with or without food, or as directed.

Medications which reduce or completely block stomach acid (e.g., proton pump inhibitors/PPIs, H2 blockers, antacids) may decrease the absorption of gefitinib. This could decrease the effectiveness of gefitinib. Consult your doctor or pharmacist if you are taking any of these medications.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day...

Our Advantage:

 
Rich experience Our company have a history of over 10 years and branch offices all around China.
Top quality All products are carefully tested and most of the purity can up to 99%, COA is available.
Competitive price We are the manufacture, so we have the most competitive price.
Safe packing Discreet package will be applied, or as you required.
Safe customs clearance Our customs clearance pass rate is above 99%.
Fast delivery We will delivery your parcel within 24 hours after payment.
Warm after service You can Contact us any time, we will try our best to offer you the best service.

Related products:
 
Product name CAS number
Dexketoprofen trometamol 156604-79-4
(S)-(+)-Ketoprofen 22161-81-5
Sodium octadecyl fumarate 4070-80-8
Cinnamyl acetate  103-54-8
Cetirizine hydrochloride 83881-52-1
Tirofiban hydrochloride monohydrate  150915-40-5 
TERAZOSIN HYDROCHLORIDE 63074-08-8 
Cyproheptadine hydrochloride  41354-29-4 
Propranolol hydrochloride  318-98-9 
Naftifine hydrochloride 65473-14-5 
Ritodrine hydrochloride  23239-51-2 
Flavoxate hydrochloride  3717-88-2 
Fexofenadine hydrochloride  153439-40-8
DULOXETINE HYDROCHLORIDE 136434-34-9 
Imipenem  64221-86-9 
Ambroxol  18683-91-5 
Oxaliplatin   61825-94-3 
Budesonide  51333-22-3
Halofuginone 55837-20-2 
 Reserpine  50-55-5 
Oseltamivir phosphate  204255-11-8
Netilmicin sulfate 56391-57-2
Choline chloride  67-48-1
Loratadine  Loratadine 

If you have any questions, please feel free to contact me:

Tel: +8618872220738

  EGFR Gefitinib White Raw Powder CAS: 184475-35-2 with Top Quality

Technical Data:

M. Wt: 446.9
Formula: C22H24ClFN4O3
Storage: Store at RT
Purity: ≥98% (HPLC)
CAS Number: 184475-35-2
PubChem ID: 123631
InChI Key: XGALLCVXEZPNRQ-UHFFFAOYSA-N
Solubility: DMSO (44.69), ethanol (4.47)

COA:

 
Product name  
Gefitinib
 
CAS No.  
184475-35-2
Outer Packing  
1KG
 
Production date  
May,05,2016
Shelf life  
May.04,2019
Standard adopted  
 
house standard
Items of analysis Specification Results
 
 
Appearance
 
 
White to off-white powder
 
 
off-White powder
 
 
Identifcation
 
 
HPLC(RT)
 
 
Complies
 
 
Loss on drying
 
 
≤ 0.5%
 
 
0.13%
 
 
Residue on ignition
 
 
≤0.,1%
 
 
0.1%
 
 
Max Single Impurity
 
 
≤ 0.10 %
 
 
0.09%
 
 
Total Impurity
 
 
≤.1.0%
 
 
0.24%
 
 
Purity(HPLC)
 
 
≥99%
 
 
99.76%
Conclusion Qualified

Mechanism of action:

Gefitinib is the first selective inhibitor of epidermal growth factor receptor's (EGFR) tyrosine kinase domain. Thus gefitinib is an EGFR inhibitor. The target protein (EGFR) is a member of a family of receptors (ErbB) which includes Her1(EGFR), Her2(erb-B2), Her3(erb-B3) and Her4 (Erb-B4). EGFR is overexpressed in the cells of certain types of human carcinomas - for example in lung and breast cancers. This leads to inappropriate activation of the anti-apoptotic Ras signalling cascade, eventually leading to uncontrolled cell proliferation. Research on gefitinib-sensitive non-small cell lung cancers has shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways.These mutations tend to confer increased sensitivity to tyrosine kinase inhibitors such as gefitinib and erlotinib. Of the types of non-small cell lung cancer histologies, adenocarcinoma is the type that most often harbors these mutations. These mutations are more commonly seen in Asians, women, and non-smokers (who also tend to more often have adenocarcinoma).

Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme.Thus the function of the EGFR tyrosine kinase in activating the anti-apoptotic Ras signal transduction cascade is inhibited, and malignant cells are inhibited.

How to use Gefitinib Tablet:

Take gefitinib by mouth once daily, with or without food, or as directed.

Medications which reduce or completely block stomach acid (e.g., proton pump inhibitors/PPIs, H2 blockers, antacids) may decrease the absorption of gefitinib. This could decrease the effectiveness of gefitinib. Consult your doctor or pharmacist if you are taking any of these medications.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day...

Our Advantage:

 
Rich experience Our company have a history of over 10 years and branch offices all around China.
Top quality All products are carefully tested and most of the purity can up to 99%, COA is available.
Competitive price We are the manufacture, so we have the most competitive price.
Safe packing Discreet package will be applied, or as you required.
Safe customs clearance Our customs clearance pass rate is above 99%.
Fast delivery We will delivery your parcel within 24 hours after payment.
Warm after service You can Contact us any time, we will try our best to offer you the best service.

Related products:
 
Product name CAS number
Dexketoprofen trometamol 156604-79-4
(S)-(+)-Ketoprofen 22161-81-5
Sodium octadecyl fumarate 4070-80-8
Cinnamyl acetate  103-54-8
Cetirizine hydrochloride 83881-52-1
Tirofiban hydrochloride monohydrate  150915-40-5 
TERAZOSIN HYDROCHLORIDE 63074-08-8 
Cyproheptadine hydrochloride  41354-29-4 
Propranolol hydrochloride  318-98-9 
Naftifine hydrochloride 65473-14-5 
Ritodrine hydrochloride  23239-51-2 
Flavoxate hydrochloride  3717-88-2 
Fexofenadine hydrochloride  153439-40-8
DULOXETINE HYDROCHLORIDE 136434-34-9 
Imipenem  64221-86-9 
Ambroxol  18683-91-5 
Oxaliplatin   61825-94-3 
Budesonide  51333-22-3
Halofuginone 55837-20-2 
 Reserpine  50-55-5 
Oseltamivir phosphate  204255-11-8
Netilmicin sulfate 56391-57-2
Choline chloride  67-48-1
Loratadine  Loratadine 

If you have any questions, please feel free to contact me:

Tel: +8618872220738

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