Chinese medical experts discover potential therapeutic targets for childhood acute lymphoblastic leukemia

April 16, 2019 Source: China News Network

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Zhongxin Online Haihai April 15 (Chen Jing Jiang Rong) Children with acute lymphoblastic leukemia (ALL) is one of the most common malignant tumors in children.

The National Children's Medical Center and the Shanghai Children's Medical Center affiliated to Shanghai Jiao Tong University School of Medicine disclosed on the 15th that the team of professors of the hospital, Professor Zhou Binbing, and the team of the â€œNational Key Research and Development Program Young Scientists Projectâ€, the chief scientist of the National Key Research and Development Program, Mr. Duan Wenwen, collaborated and researched Blocking the relevant signaling pathways of ALL cells can significantly improve the chemotherapy effect of ALL, which is of great significance for the joint treatment of ALL in the later stage of clinical.

According to reports, at this stage, the cure rate of Chinese children's ALL is about 70%. The patient's resistance to the relevant treatment drugs, and the resulting recurrence, is a "bottleneck" that is difficult to improve the cure rate. Therefore, how to solve the drug relapse and its clonal evolution mechanism in children has become the focus of research in this field.

The researchers found that chemotherapy caused genetic damage in ALL cells, activated the relevant pathways, and formed a microenvironment that protects residual leukemia cells in the bone marrow after a series of mechanisms, which became the basis for relapse and mutation of ALL. After blocking the relevant signaling pathways, the researchers combined with clinical first-line chemotherapy drugs, the number of minimal residual leukemia cells was significantly reduced, and the effect of ALL chemotherapy was improved. The research results reveal potential therapeutic targets for overcoming the relapse of ALL resistance, and lay a solid theoretical foundation for further improving the cure rate of Chinese children's ALL. This latest research was published in Leukemia, the internationally leading academic journal of hematology.

Professor Adolfo Ferrando, an international expert on blood diseases and a professor of cancer genetics at Columbia University, highly affirmed the results of this study and said that the relapse of resistance to ALL is a worldwide problem. It is very important to block related signaling pathways and improve the efficacy of ALL chemotherapy. Translation and therapeutic significance.

According to reports, the project has received joint support from the national key research and development program, the National Natural Science Foundation (key projects) and the 973 sub-project. Professor Chen Hong, director of the Shanghai Translational Medicine Collaborative Innovation Center, fully participated in the research and said that it will support the deepening of this research project and expect to realize technological transformation and benefit patients as soon as possible.

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